January20 , 2026

    Oprah Winfrey feels ‘more alive’ because of weight-loss medication

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    Oprah Winfrey feels “more alive and more vibrant” since she started using GLP-1.

    Oprah Winfrey has opened up about her weight-loss journey

    The 71-year-old TV star started using weight-loss medication two and a half years ago, and she admits that GLP-1 has transformed her life.

    Oprah told People: “I thought it was about discipline and willpower. But I stopped blaming myself.

    “I feel more alive and more vibrant than I’ve ever been.”

    Oprah admits that she now feels happier in her own skin.

    She said: “I’m not constantly punishing myself. I hardly recognise the woman I’ve become. But she’s a happy woman.”

    By contrast, Oprah previously felt “embarrassed” by her appearance.

    She explained: “I’ve always been confident in whatever I was doing, but I was at the same time disappointed in my overweight body.

    “Was I embarrassed by it? Yes. Was I disappointed in myself for continuing to fail? Yes, every single time. I felt it was my fault.”

    Meanwhile, Oprah previously revealed that she once declined a party invite because she thought she was “too fat”.

    The TV star embarked on a weight-loss journey in the late 1980s – but Oprah found that in spite of her best efforts, she quickly regained the weight that she’d lost.

    During an appearance on The Jamie Kern Lima Show, Oprah shared: “I didn’t have a morsel of food for five solid months in losing that weight on [the all-liquid diet] Optifast.

    “Three days later, I was 5 lbs. heavier, and a week later I was 10 lbs. heavier.

    “The week before Christmas, I remember Don Johnson – the Don Johnson, of Miami Vice – was having a party and had invited me and some members of my show to come, and I wouldn’t go because I thought I was too fat to go.”

    Oprah recalled feeling a sense of shame about her weight struggles.

    She said: “I’d gone from 145 [lbs.] on the day of the show. I think I was 157 [lbs.] in the course of, like, a week and a half or two. And the shame started again.”






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