March14 , 2026

    ‘Grey’s Anatomy’ Season 21 Cast Changes for 2024: Multiple Actors Are Leaving, New Characters Introduced & Many Returning Stars!

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    Grey’s Anatomy is returning for season 21 TONIGHT (September 26) and the show has a new time slot… along with some new cast members!

    We’ve already learned big details about the next season, including a former star who is coming back, two actors who will leave the show in the coming season, and Ellen Pompeo‘s status this year.

    Many other cast members will be back for the upcoming season, but there’s a catch involved with some of the main stars.

    Browse through the slideshow to see everything we know so far about the upcoming Grey’s Anatomy season





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